I ka hoʻomaka ʻana o 2025, ua hōʻike nā mea noiʻi mai ke Kulanui o Wakinekona a me Brigham and Women's Hospital (kahi haukapila aʻo o ke Kula Lapaʻau ʻo Harvard) i kahi ʻano hana i manaʻo ʻole ʻia no ka mālama ʻana i ka maʻi Alzheimer - ka hanu ʻanaxenonkinoea, ʻaʻole wale e kāohi i ka neuroinflammation a hōʻemi i ka atrophy o ka lolo, akā hoʻonui pū i nā kūlana neuronal pale.

Xenona me ka Neuroprotection

ʻO ka maʻi Alzheimer ka maʻi neurodegenerative maʻamau i loko o ke kanaka, a ua manaʻo ʻia kona kumu e pili ana i ka hōʻiliʻili ʻana o ka protein tau a me ka protein beta-amyloid i loko o ka lolo. ʻOiai ua loaʻa nā lāʻau lapaʻau e hoʻāʻo nei e wehe i kēia mau protein ʻawahia, ʻaʻole lākou i kūleʻa i ka hoʻolohi ʻana i ka holomua o ka maʻi. No laila, ʻaʻole maopopo loa ke kumu o ka maʻi a me ka lāʻau lapaʻau.

Ua hōʻike ʻia nā haʻawina ua hanu ʻiaxenonhiki ke hele i ke ālai koko-lolo a hoʻomaikaʻi nui i ke kūlana o nā ʻiole me nā maʻi maʻi Alzheimer ma lalo o nā kūlana hoʻokolohua.Ua māhele ʻia ka hoʻokolohua i ʻelua mau pūʻulu, ua hōʻike kekahi hui o nā ʻiole i ka hōʻiliʻili ʻana o ka protein tau a ʻo kekahi hui i loaʻa ka hōʻiliʻili ʻana o ka protein beta-amyloid. Ua hōʻike nā hopena hoʻokolohua ʻaʻole i hoʻoikaika wale ka xenon i nā ʻiole, akā ua hoʻolaha pū i ka pane pale o microglia, he mea nui ia no ka hoʻomaʻemaʻe ʻana i nā protein tau a me beta-amyloid.

He mea hou loa kēia ʻike hou, e hōʻike ana hiki ke hana ʻia nā hopena neuroprotective ma ka hanu wale ʻana i kahi kinoea inert. ʻO kahi palena nui i ke kahua o ka noiʻi a me ka mālama ʻana o Alzheimer, ʻo ia ka paʻakikī loa o ka hoʻolālā ʻana i nā lāʻau lapaʻau e hiki ke hele i ke pale koko-lolo, axenonhiki ke hana i kēia.

Nā hoʻohana lapaʻau ʻē aʻe o xenon

1. Anesthesia a me ka analgesia: Ma ke ʻano he kinoea anesthetic kūpono,xenonhoʻohana nui ʻia ma muli o kona hoʻoulu wikiwiki ʻana a me ka hoʻōla hou ʻana, kūpaʻa cardiovascular maikaʻi a me ka haʻahaʻa o ka pilikia o nā hopena ʻaoʻao;

2. Ka hopena neuroprotective: Ma waho aʻe o ka hopena therapeutic hiki ke loaʻa i ka maʻi Alzheimer i ʻōlelo ʻia ma luna, ua aʻo ʻia hoʻi ka xenon e hōʻemi i ka hōʻino ʻana o ka lolo i hoʻokumu ʻia e ka neonatal hypoxic-ischemic encephalopathy (HIE);

3. Ka hoʻoili ʻana a me ka pale ʻana i nā kino:Xenonhiki ke kōkua i ka pale ʻana i nā ʻōpū mea hāʻawi mai ka hōʻeha ischemia-reperfusion, he mea nui loa ia no ka hoʻomaikaʻi ʻana i ka holomua o ka hoʻoili ʻana;

4. Ka hoʻonui ʻana i ka radiotherapy: Ua hōʻike kekahi mau haʻawina mua e hiki i ka xenon ke hoʻonui i ka ʻike o nā ʻōpū i ka radiotherapy, kahi e hāʻawi ai i kahi hoʻolālā hou no ka mālama ʻana i ka maʻi kanesa;